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Article

ANP in regulation of arterial pressure and fluid-electrolyte balance: lessons from genetic mouse models.

Physiological genomics - 29 Jun 2000

Melo L G, Steinhelper M E, Pang S C, Tse Y, Ackermann U

Abstract excerpt

The recent development of genetic mouse models presenting life-long alterations in expression of the genes for atrial natriuretic peptide (ANP) or its receptors (NPR-A, NPR-C) has uncovered a physiological role of this hormone in chronic blood pressure homeostasis. Transgenic mice overexpressing a transthyretin-ANP fusion gene are hypotensive relative to the nontransgenic littermates, whereas mice harboring...

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Identifiers

PMID: 11015600
DOI: 10.1152/physiolgenomics.2000.3.1.45

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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