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Article

The role of collagen in extralobar pulmonary artery stiffening in response to hypoxia-induced pulmonary hypertension.

American journal of physiology. Heart and circulatory physiology - 1 Dec 2010

Ooi Chen Yen, Wang Zhijie, Tabima Diana M, Eickhoff Jens C, Chesler Naomi C

Abstract excerpt

Hypoxic pulmonary hypertension (HPH) causes extralobar pulmonary artery (PA) stiffening, which potentially impairs right ventricular systolic function. Changes in the extracellular matrix proteins collagen and elastin have been suggested to contribute to this arterial stiffening. We hypothesized that vascular collagen accumulation is a major cause of extralobar PA stiffening in HPH and tested our hypothesis with...

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Source

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Identifiers

PMID: 20852040
DOI: 10.1152/ajpheart.00493.2009
PMCID: PMC3006281

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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