Article
A human atrial natriuretic peptide gene mutation reveals a novel peptide with enhanced blood pressure-lowering, renal-enhancing, and aldosterone-suppressing actions.
Journal of the American College of Cardiology - 8 Sept 2009
McKie Paul M, Cataliotti Alessandro, Huntley Brenda K, Martin Fernando L, Olson Timothy M, Burnett John C
Abstract excerpt
OBJECTIVES: We sought to determine the physiologic actions and potential therapeutic applications of mutant atrial natriuretic peptide (mANP). BACKGROUND: The cardiac hormone atrial natriuretic peptide (ANP) is a 28-amino acid (AA) peptide that consists of a 17-AA ring structure together with a 6-AA N-terminus and a 5-AA C-terminus. In a targeted scan for sequence variants within the human ANP gene, a mutation...
Topics
- Animals
- Arrhythmias, Cardiac
- Atrial Natriuretic Factor
- Blood Pressure
- Cell Culture Techniques
- Cyclic GMP
- Dogs
- Fibroblasts
- Glomerular Filtration Rate
- Humans
- Mutant Proteins
- Mutation
- Myocardium