Article
Different cardiovascular and pulmonary phenotypes for single- and double-knock-out mice deficient in BMP9 and BMP10.
Cardiovascular research - 22 Jun 2022
Bouvard Claire, Tu Ly, Rossi Martina, Desroches-Castan Agnès, Berrebeh Nihel, Helfer Elise, Roelants Caroline, Liu Hequn, Ouarné Marie, Chaumontel Nicolas, Mallet Christine, Battail Christophe, Bikfalvi Andreas, Humbert Marc, Savale Laurent, Daubon Thomas, Perret Pascale, Tillet Emmanuelle, Guignabert Christophe, Bailly Sabine
Abstract excerpt
AIMS: BMP9 and BMP10 mutations were recently identified in patients with pulmonary arterial hypertension, but their specific roles in the pathogenesis of the disease are still unclear. We aimed to study the roles of BMP9 and BMP10 in cardiovascular homeostasis and pulmonary hypertension using transgenic mouse models deficient in Bmp9 and/or Bmp10. METHODS AND RESULTS: Single- and double-knockout mice for Bmp9...
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