Article
Multiple genetic diagnoses from single cells using multiplex PCR: reliability and allele dropout.
Prenatal diagnosis - 1 Dec 1998
Findlay I, Matthews P, Quirke P
Abstract excerpt
We used a multiplex fluorescent PCR system containing seven primer sets on single cells from three different cell types (buccal, corneal and blastomere cells) and more than 3500 heterozygous alleles to investigate reliability and extent of allele dropout in multiplex PCRs at the single cell level. All three cell types gave similarly high reliability, accuracy and allele dropout rates, with similar reliability...
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