Allele dropout in polar bodies and blastomeres.

doi:10.1023/a:1022532108472

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Article

Allele dropout in polar bodies and blastomeres.

Journal of assisted reproduction and genetics - 1 May 1998

Rechitsky S, Strom C, Verlinsky O, Amet T, Ivakhnenko V, Kukharenko V, Kuliev A, Verlinsky Y

Abstract excerpt

PURPOSE: Because allele dropout (ADO) is frequently observed in single-cell polymerase chain reaction analysis, it is important to develop a method for efficient detection of ADO, in order to avoid possible misdiagnosis in preimplantation diagnosis. METHODS: We introduced a simultaneous amplifica...

Topics

Alleles
Anemia, Sickle Cell
Blastomeres
Cystic Fibrosis
Cystic Fibrosis Transmembrane Conductance Regulator
DNA Probes
Female
Fibroblasts
Globins
Humans
Polymerase Chain Reaction
Preimplantation Diagnosis

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