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Article

A prospective study of NAT2 acetylation genotype, cigarette smoking, and risk of breast cancer.

Carcinogenesis - 1 Nov 1997

Hunter D J, Hankinson S E, Hough H, Gertig D M, Garcia-Closas M, Spiegelman D, Manson J E, Colditz G A, Willett W C, Speizer F E, Kelsey K

Abstract excerpt

Polymorphisms in the N-acetyltransferase 2 (NAT2) gene are determinants of the rate of metabolic activation of carcinogenic compounds such as aryl aromatic amines. Homozygosity for any combination of three variant alleles in Caucasians defines 'slow' acetylators; presence of one or two wild-type alleles characterizes 'rapid' acetylators. Although most previous studies have not observed an overall elevation in...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 9395212
DOI: 10.1093/carcin/18.11.2127

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A prospective study of NAT2 acetylation genotype, cigarette smoking, and risk of breast cancer.PMID 9395212Read ↗

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NAT2 slow acetylator genotype as an important modifier of breast cancer risk.Semantic proximity Read ↗

NAT2 polymorphisms combining with smoking associated with breast cancer susceptibility: a meta-analysis.Semantic proximity Read ↗

A meta-analysis of the association of N-acetyltransferase 2 gene (NAT2) variants with breast cancer.Semantic proximity Read ↗

NAT2 slow acetylation and GSTM1 null genotypes may increase postmenopausal breast cancer risk in long-term smoking women.Semantic proximity Read ↗

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