A prospective study of NAT2 acetylation genotype, cigarette smoking, and risk of breast cancer.

doi:10.1093/carcin/18.11.2127

Article

A prospective study of NAT2 acetylation genotype, cigarette smoking, and risk of breast cancer.

Carcinogenesis - 1 Nov 1997

Hunter D J, Hankinson S E, Hough H, Gertig D M, Garcia-Closas M, Spiegelman D, Manson J E, Colditz G A, Willett W C, Speizer F E, Kelsey K

Abstract excerpt

Polymorphisms in the N-acetyltransferase 2 (NAT2) gene are determinants of the rate of metabolic activation of carcinogenic compounds such as aryl aromatic amines. Homozygosity for any combination of three variant alleles in Caucasians defines 'slow' acetylators; presence of one or two wild-type...

Topics

Acetylation
Aged
Arylamine N-Acetyltransferase
Breast Neoplasms
Female
Genotype
Humans
Middle Aged
Prospective Studies
Risk Factors
Smoking

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