Mutation at chromosome 11q23 in human non-familial breast cancer: a microdissection microsatellite analysis.

doi:10.1002/path.1711760104

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Article

Mutation at chromosome 11q23 in human non-familial breast cancer: a microdissection microsatellite analysis.

The Journal of pathology - 1 May 1995

Koreth J, Bethwaite P B, McGee J O

Abstract excerpt

Allelotypic evaluation of loss of heterozygosity (LOH) has been instrumental in the identification of tumour suppressor genes. Here we report a high incidence of LOH at chromosome 11q23 in non-familial breast cancers with in situ, invasive, and metastatic tumour cells microdissected from archival haematoxylin and eosin (H & E) sections for polymerase chain reaction (PCR)-LOH analysis at polymorphic microsatellite...

Topics

Adult
Aged
Blotting, Southern
Breast Neoplasms
Carcinoma in Situ
Carcinoma, Ductal, Breast
Chromosomes, Human, Pair 11
DNA, Neoplasm
DNA, Satellite
Female
Heterozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Lymphatic Metastasis

Middle Aged

Mutation

Neoplasm Invasiveness

Polymerase Chain Reaction

Polymorphism, Restriction Fragment Length

Source

Open in PubMed

Identifiers

PMID: 7616353
DOI: 10.1002/path.1711760104

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7616353-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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