Article
Mutation at chromosome 11q23 in human non-familial breast cancer: a microdissection microsatellite analysis.
The Journal of pathology - 1 May 1995
Koreth J, Bethwaite P B, McGee J O
Abstract excerpt
Allelotypic evaluation of loss of heterozygosity (LOH) has been instrumental in the identification of tumour suppressor genes. Here we report a high incidence of LOH at chromosome 11q23 in non-familial breast cancers with in situ, invasive, and metastatic tumour cells microdissected from archival haematoxylin and eosin (H & E) sections for polymerase chain reaction (PCR)-LOH analysis at polymorphic microsatellite...
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