Article
Loss of heterozygosity on chromosome 11q22-23 in melanoma is associated with retention of the insertion polymorphism in the matrix metalloproteinase-1 promoter.
The American journal of pathology - 1 Feb 2001
Noll W W, Belloni D R, Rutter J L, Storm C A, Schned A R, Titus-Ernstoff L, Ernstoff M S, Brinckerhoff C E
Abstract excerpt
Matrix metalloproteinase-1 (MMP-1, collagenase-1), which degrades interstitial collagen, is expressed at high levels by some tumor cells and is thought to enhance their invasiveness and metastatic potential. We recently described a common single nucleotide insertion polymorphism (2G allele) at -1,607 bp in the promoter of the MMP-1 gene that creates a binding site for the ETS family of transcription factors, and...
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