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Article

Chemopreventive agents inhibit aberrant proliferation of the aneuploid phenotype in a colon epithelial cell line established from Apc 1638N [+/-] mouse.

Annals of the New York Academy of Sciences - 1 Dec 2001

Katdare M, Kopelovich L, Telang N

Abstract excerpt

Loss of function of the adenomatous polyposis coli (APC) tumor suppressor gene predisposes for familial adenomatous polyposis (FAP) syndrome. The Apc gene knockout mice exhibit accelerated intestinal carcinogensis modifiable by diverse pharmacological agents. Present experiments utilized the Apc[+/-] 1638N COL colon epithelial cell line (origin: histologically normal colon) as the model. Retinoid receptor...

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Aneuploidy
Anti-Inflammatory Agents, Non-Steroidal
Anticarcinogenic Agents
Colon
Genes, APC

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Intestinal Mucosa

Receptors, Retinoic Acid

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Identifiers

PMID: 11795437
DOI: 10.1111/j.1749-6632.2001.tb02738.x

Genes

FAP
APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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