Article
Mouse models for the study of colon carcinogenesis.
Carcinogenesis - 1 Feb 2009
Rosenberg Daniel W, Giardina Charles, Tanaka Takuji
Abstract excerpt
The study of experimental colon carcinogenesis in rodents has a long history, dating back almost 80 years. There are many advantages to studying the pathogenesis of carcinogen-induced colon cancer in mouse models, including rapid and reproducible tumor induction and the recapitulation of the adenoma-carcinoma sequence that occurs in humans. The availability of recombinant inbred mouse panels and the existence of...
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