Article
Functional analysis of a human tumor necrosis factor alpha (TNF-alpha) promoter polymorphism related to joint damage in rheumatoid arthritis.
Molecular medicine (Cambridge, Mass.) - 1 Nov 1998
Kaijzel E L, van Krugten M V, Brinkman B M, Huizinga T W, van der Straaten T, Hazes J M, Ziegler-Heitbrock H W, Nedospasov S A, Breedveld F C, Verweij C L
Abstract excerpt
BACKGROUND: Functional heterogeneity in the tumor necrosis factor alpha (TNF-alpha) gene may be responsible for the TNF-alpha response in infectious and autoimmune diseases. Recently, the TNF-238 promoter polymorphism was observed as being associated with a more destructive disease in rheumatoid...
Topics
- Adult
- Alleles
- Arthritis, Rheumatoid
- Case-Control Studies
- Cell Line
- Cohort Studies
- Gene Frequency
- Genotype
- Humans
- Linkage Disequilibrium
- Lymphocytes
- Middle Aged
- Monocytes
- Polymorphism, Genetic