Article
Functional analysis of a human tumor necrosis factor alpha (TNF-alpha) promoter polymorphism related to joint damage in rheumatoid arthritis.
Molecular medicine (Cambridge, Mass.) - 1 Nov 1998
Kaijzel E L, van Krugten M V, Brinkman B M, Huizinga T W, van der Straaten T, Hazes J M, Ziegler-Heitbrock H W, Nedospasov S A, Breedveld F C, Verweij C L
Abstract excerpt
BACKGROUND: Functional heterogeneity in the tumor necrosis factor alpha (TNF-alpha) gene may be responsible for the TNF-alpha response in infectious and autoimmune diseases. Recently, the TNF-238 promoter polymorphism was observed as being associated with a more destructive disease in rheumatoid arthritis (RA). To determine the relation between TNF-238 and disease progression, the extent of joint destruction in a...
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