Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional analysis of linker-scan mutants spanning the -376, -308, -244, and -238 polymorphic sites of the TNF-alpha promoter.

Cytokine - 21 Jun 2001

Bayley J P, de Rooij H, van den Elsen P J, Huizinga T W, Verweij C L

Abstract excerpt

Tumor necrosis factor alpha (TNF-alpha) promoter polymorphisms have been linked to a large number of diseases but studies examining the possible direct functional effects of these polymorphisms have been contradictory. Previous studies compared TNF-alpha promoter constructs containing single nucleotide changes. We have now made a series of mutant constructs in which regions of the TNF-alpha promoter containing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to B-Lymphocytes
Share to Jurkat Cells
Share to Lymphocyte Activation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to T-Lymphocytes

Share to Transcription, Genetic

Share to Transfection

Share to Tumor Necrosis Factor-alpha

Share to U937 Cells

Source

Identifiers

PMID: 11497492
DOI: 10.1006/cyto.2001.0902

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional analysis of linker-scan mutants spanning the -376, -308, -244, and -238 polymorphic sites of the TNF-alpha promoter.PMID 11497492Read ↗

TNFalpha promoter polymorphisms.Semantic proximity Read ↗

Functional study of TNF-α promoter polymorphisms: literature review and meta-analysis.Semantic proximity Read ↗

Functional analysis of a human tumor necrosis factor alpha (TNF-alpha) promoter polymorphism related to joint damage in rheumatoid arthritis.Semantic proximity Read ↗

Functional Consequences of a Polymorphism Affecting NF-κB p50-p50 Binding to the <i>TNF</i> Promoter RegionSemantic proximity Read ↗

A critical assessment of the factors affecting reporter gene assays for promoter SNP function: a reassessment of -308 TNF polymorphism function using a novel integrated reporter system.Semantic proximity Read ↗

Functional analysis of a new polymorphism in the human TNF alpha gene promoter.Semantic proximity Read ↗

Allele-specific chromatin remodeling of the tumor necrosis factor-alpha promoter.Semantic proximity Read ↗

Effects of a single nucleotide polymorphism on the expression of human tumor necrosis factor-alpha.Semantic proximity Read ↗

Genetic polymorphism at position-308 in the promoter region of the tumor necrosis factor (TNF): implications of its allelic distribution on susceptibility or resistance to diseases in the Chilean population.Semantic proximity Read ↗

A TNF variant that associates with susceptibility to musculoskeletal disease modulates thyroid hormone receptor binding to control promoter activation.Semantic proximity Read ↗

Different Transcriptional Activity and In Vitro TNF-α Production in Psoriasis Patients Carrying the TNF-α 238A Promoter PolymorphismSemantic proximity Read ↗

Relevance of the tumor necrosis factor alpha (TNF alpha) -308 promoter polymorphism in TNF alpha gene regulation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.