Article
Polymorphisms in genes controlling inflammation and tissue repair in rheumatoid arthritis: a case control study.
BMC medical genetics - 7 Mar 2011
Emonts Marieke, Hazes Mieke J M W, Houwing-Duistermaat Jeanine J, van der Gaast-de Jongh Christa E, de Vogel Lisette, Han Huub K H, Wouters Jacques M G W, Laman Jon D, Dolhain Radboud J E M
Abstract excerpt
BACKGROUND: Various cytokines and inflammatory mediators are known to be involved in the pathogenesis of rheumatoid arthritis (RA). We hypothesized that polymorphisms in selected inflammatory response and tissue repair genes contribute to the susceptibility to and severity of RA. METHODS: Polymorphisms in TNFA, IL1B, IL4, IL6, IL8, IL10, PAI1, NOS2a, C1INH, PARP, TLR2 and TLR4 were genotyped in 376 Caucasian RA...
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