Article
PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignancies.
Human molecular genetics - 1 Feb 1999
Dahia P L, Aguiar R C, Alberta J, Kum J B, Caron S, Sill H, Marsh D J, Ritz J, Freedman A, Stiles C, Eng C
Abstract excerpt
PTEN is a novel tumour suppressor gene that encodes a dual-specificity phosphatase with homology to adhesion molecules tensin and auxillin. It recently has been suggested that PTEN dephosphorylates phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3, 4,5)P3], which mediates growth factor-induced a...
Topics
- Blotting, Northern
- DNA Mutational Analysis
- DNA, Neoplasm
- Gene Expression Regulation, Neoplastic
- HL-60 Cells
- Hematologic Neoplasms
- Humans
- K562 Cells
- Methylation
- Mutation
- Neoplasm Proteins
- PTEN Phosphohydrolase
- Phosphoric Monoester Hydrolases
- Protein Serine-Threonine Kinases