Article
PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignancies.
Human molecular genetics - 1 Feb 1999
Dahia P L, Aguiar R C, Alberta J, Kum J B, Caron S, Sill H, Marsh D J, Ritz J, Freedman A, Stiles C, Eng C
Abstract excerpt
PTEN is a novel tumour suppressor gene that encodes a dual-specificity phosphatase with homology to adhesion molecules tensin and auxillin. It recently has been suggested that PTEN dephosphorylates phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3, 4,5)P3], which mediates growth factor-induced activation of intracellular signalling, in particular through the serine-threonine kinase Akt, a known cell...
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