Article
Safeguarding entry into mitosis: the antephase checkpoint.
Molecular and cellular biology - 1 Jan 2010
Chin Cheen Fei, Yeong Foong May
Abstract excerpt
Maintenance of genomic stability is needed for cells to survive many rounds of division throughout their lifetime. Key to the proper inheritance of intact genome is the tight temporal and spatial coordination of cell cycle events. Moreover, checkpoints are present that function to monitor the proper execution of cell cycle processes. For instance, the DNA damage and spindle assembly checkpoints ensure genomic...
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