Tissue-specific distribution of multiple mitochondrial DNA rearrangements during human aging.

doi:10.1111/j.1749-6632.1998.tb09900.x

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Article

Tissue-specific distribution of multiple mitochondrial DNA rearrangements during human aging.

Annals of the New York Academy of Sciences - 20 Nov 1998

Kovalenko S A, Kopsidas G, Kelso J, Rosenfeldt F, Linnane A W

Abstract excerpt

Mitochondria, according to the free radical theory of aging, are the major source of reactive oxygen species (ROS). The results, presented in this paper, question the role of reactive oxygen species in contributing significantly to the extent of mitochondrial bioenergy degradation of the tissues,...

Topics

Aged
Aging
Animals
DNA Damage
DNA, Mitochondrial
Electron Transport Complex IV
Humans
Mitochondria
Mitochondria, Heart
Mitochondria, Liver
Mitochondria, Muscle
Mutation
Organ Specificity
Reactive Oxygen Species

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