Article
Tissue-specific distribution of multiple mitochondrial DNA rearrangements during human aging.
Annals of the New York Academy of Sciences - 20 Nov 1998
Kovalenko S A, Kopsidas G, Kelso J, Rosenfeldt F, Linnane A W
Abstract excerpt
Mitochondria, according to the free radical theory of aging, are the major source of reactive oxygen species (ROS). The results, presented in this paper, question the role of reactive oxygen species in contributing significantly to the extent of mitochondrial bioenergy degradation of the tissues, which can be correlated with mtDNA rearrangements. We report here that mtDNA rearrangements, including deletions and...
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