Article
Oxidative stress and mitochondrial impairment can be separated from lipofuscin accumulation in aged human skeletal muscle
5 Feb 2007
Abstract excerpt
According to the free radical theory of aging, reactive oxygen species (ROS) act as a driving force of the aging process, and it is generally believed that mitochondrial dysfunction is a major source of increased oxidative stress in tissues with high content of mitochondria, such as muscle or brain. However, recent experiments in mouse models of premature aging have questioned the role of mitochondrial ROS...
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