Tissue‐specific mtDNA lesions and radical‐associated mitochondrial dysfunction in human hearts exposed to doxorubicin

Abstract excerpt

Doxorubicin causes a chronic cardiomyopathy. Although the exact pathogenesis is unknown, recent animal data suggest that somatically acquired alterations of mitochondrial DNA (mtDNA) and concomitant mitochondrial dysfunction play an important role in its onset. In this study, skeletal and myocardial muscles were examined from human autopsies. Compared to controls (n = 8), doxorubicin-exposed hearts (n = 6) showed...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to ATP Synthase and ATPases Research
• Share to Chemotherapy-induced cardiotoxicity and mitigation
• Share to Mitochondrial Function and Pathology