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Response to the increase of oxidative stress and mutation of mitochondrial DNA in aging.

Biochimica et biophysica acta - 1 Oct 2009

Ma Yi-Shing, Wu Shi-Bei, Lee Wan-Yu, Cheng Ju-San, Wei Yau-Huei

Abstract excerpt

In the aging process, mitochondrial function gradually declines with an increase of mutations in mitochondrial DNA (mtDNA) in tissue cells. Some of the aging-associated mtDNA mutations have been shown to result in not only inefficient generation of ATP but also increased production of reactive oxygen species (ROS) such as superoxide anions (O2-) and hydrogen peroxide (H2O2) in the mitochondria of aging tissues....

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Identifiers

PMID: 19397952
DOI: 10.1016/j.bbagen.2009.04.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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