Article
Role for Msh5 in the regulation of Ig class switch recombination.
Proceedings of the National Academy of Sciences of the United States of America - 24 Apr 2007
Sekine Hideharu, Ferreira Ricardo C, Pan-Hammarström Qiang, Graham Robert R, Ziemba Beth, de Vries Sandra S, Liu Jiabin, Hippen Keli, Koeuth Thearith, Ortmann Ward, Iwahori Akiko, Elliott Margaret K, Offer Steven, Skon Cara, Du Likun, Novitzke Jill, Lee Annette T, Zhao Nianxi, Tompkins Joshua D, Altshuler David, Gregersen Peter K, Cunningham-Rundles Charlotte, Harris Reuben S, Her Chengtao, Nelson David L, Hammarström Lennart, Gilkeson Gary S, Behrens Timothy W
Abstract excerpt
Ig class switch recombination (CSR) and somatic hypermutation serve to diversify antibody responses and are orchestrated by the activity of activation-induced cytidine deaminase and many proteins involved in DNA repair and genome surveillance. Msh5, a gene encoded in the central MHC class III reg...
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