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Article

Different functions for the thyroid hormone receptors TRalpha and TRbeta in the control of thyroid hormone production and post-natal development.

The EMBO journal - 1 Feb 1999

Gauthier K, Chassande O, Plateroti M, Roux J P, Legrand C, Pain B, Rousset B, Weiss R, Trouillas J, Samarut J

Abstract excerpt

The biological activities of thyroid hormones are thought to be mediated by receptors generated by the TRalpha and TRbeta loci. The existence of several receptor isoforms suggests that different functions are mediated by specific isoforms and raises the possibility of functional redundancies. We have inactivated both TRalpha and TRbeta genes by homologous recombination in the mouse and compared the phenotypes of...

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Identifiers

PMID: 9927422
DOI: 10.1093/emboj/18.3.623
PMCID: PMC1171155

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Source receipt: pubmed, retrieved 7 Sept 2026.

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