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Article

Genetic analysis reveals different functions for the products of the thyroid hormone receptor alpha locus.

Molecular and cellular biology - 1 Jul 2001

Gauthier K, Plateroti M, Harvey C B, Williams G R, Weiss R E, Refetoff S, Willott J F, Sundin V, Roux J P, Malaval L, Hara M, Samarut J, Chassande O

Abstract excerpt

Thyroid hormone receptors are encoded by the TRalpha (NR1A1) and TRbeta (NR1A2) loci. These genes are transcribed into multiple variants whose functions are unclear. Analysis by gene inactivation in mice has provided new insights into the functional complexity of these products. Different strategies designed to modify the TRalpha locus have led to strikingly different phenotypes. In order to analyze the molecular...

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Identifiers

PMID: 11416150
DOI: 10.1128/MCB.21.14.4748-4760.2001
PMCID: PMC87157

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Source receipt: pubmed, retrieved 7 Sept 2026.

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