Article
Exome sequencing of hepatoblastoma reveals novel mutations and cancer genes in the Wnt pathway and ubiquitin ligase complex.
Hepatology (Baltimore, Md.) - 1 Nov 2014
Jia Deshui, Dong Rui, Jing Ying, Xu Dan, Wang Qifeng, Chen Lei, Li Qigen, Huang Yuping, Zhang Yuannv, Zhang Zhenfeng, Liu Li, Zheng Shan, Xia Qiang, Wang Hongyang, Dong Kuiran, He Xianghuo
Abstract excerpt
UNLABELLED: Hepatoblastoma (HB) is the most common primary liver tumor in children. Mutations in the β-catenin gene that lead to constitutive activation of the Wnt pathway have been detected in a large proportion of HB tumors. To identify novel mutations in HB, we performed whole-exome sequencing...
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