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Article

Role of Rho-GTPases in complement-mediated glomerular epithelial cell injury.

American journal of physiology. Renal physiology - 1 Jul 2007

Zhang Hui, Cybulsky Andrey V, Aoudjit Lamine, Zhu Jianxin, Li Hongping, Lamarche-Vane Nathalie, Takano Tomoko

Abstract excerpt

Visceral glomerular epithelial cells (GEC) are essential for maintenance of normal glomerular permselectivity. The actin cytoskeleton is a key determinant of GEC morphology and function. In the rat passive Heymann nephritis (PHN) model of membranous nephropathy, complement C5b-9 induces nonlytic GEC injury associated with morphological changes of GEC and proteinuria. The current study addresses the role of Rho...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17376765
DOI: 10.1152/ajprenal.00294.2006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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