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Article

Transcriptional regulation and biological significance of the insulin like growth factor II gene

1 Oct 1998

Abstract excerpt

The insulin like growth factors I and II are the most ubiquitous in the mammalian embryo. Moreover they play a pivotal role in the development and growth of tumours. The bioavailability of these growth factors is regulated on a transcriptional as well as on a posttranslational level. The expression of non-signalling receptors as well as binding proteins does further tune the local concentration of IGFs. This...

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PMID: 9925986
DOI: 10.1111/j.1365-2184.1998.tb01196.x

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