Coordinating cell proliferation and differentiation: Antagonism between cell cycle regulators and cell type-specific gene expression.

Abstract excerpt

Cell proliferation and differentiation show a remarkable inverse relationship. Precursor cells continue division before acquiring a fully differentiated state, while terminal differentiation usually coincides with proliferation arrest and permanent exit from the division cycle. Mechanistic insight in the temporal coordination between cell cycle exit and differentiation has come from studies of cells in culture...

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