Article
Mutant MyoD lacking Cdc2 phosphorylation sites delays M-phase entry.
Molecular and cellular biology - 1 Feb 2004
Tintignac Lionel A J, Sirri Valentina, Leibovitch Marie Pierre, Lécluse Yann, Castedo Maria, Metivier Didier, Kroemer Guido, Leibovitch Serge A
Abstract excerpt
The transcription factors MyoD and Myf-5 control myoblast identity and differentiation. MyoD and Myf-5 manifest opposite cell cycle-specific expression patterns. Here, we provide evidence that MyoD plays a pivotal role at the G(2)/M transition by controlling the expression of p21(Waf1/Cip1) (p21), which is believed to regulate cyclin B-Cdc2 kinase activity in G(2). In growing myoblasts, MyoD reaccumulates during...
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