Article
A p57 conditional mutant allele that allows tracking of p57-expressing cells.
Genesis (New York, N.Y. : 2000) - 1 Apr 2017
Mademtzoglou Despoina, Alonso-Martin Sonia, Chang Ted Hung-Tse, Bismuth Keren, Drayton-Libotte Bernadette, Aurade Frédéric, Relaix Frédéric
Abstract excerpt
p57Kip2 (p57) is a maternally expressed imprinted gene regulating growth arrest which belongs to the CIP/KIP family of cyclin-dependent kinase inhibitors. While initially identified as a cell cycle arrest protein through inhibition of cyclin and cyclin-dependent kinase complexes, p57 activity has also been linked to differentiation, apoptosis, and senescence. In addition, p57 has recently been shown to be...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.