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Article

Rb is required for progression through myogenic differentiation but not maintenance of terminal differentiation.

The Journal of cell biology - 13 Sept 2004

Huh Michael S, Parker Maura H, Scimè Anthony, Parks Robin, Rudnicki Michael A

Abstract excerpt

To investigate the requirement for pRb in myogenic differentiation, a floxed Rb allele was deleted either in proliferating myoblasts or after differentiation. Myf5-Cre mice, lacking pRb in myoblasts, died immediately at birth and exhibited high numbers of apoptotic nuclei and an almost complete absence of myofibers. In contrast, MCK-Cre mice, lacking pRb in differentiated fibers, were viable and exhibited a...

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Identifiers

PMID: 15364961
DOI: 10.1083/jcb.200403004
PMCID: PMC2172111

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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