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Article

p53-independent apoptosis induced by paclitaxel through an indirect mechanism

2 Sept 1997

Abstract excerpt

The efficacy of chemotherapeutic agents may be determined by a number of different factors, including the genotype of the tumor cell. The p53 tumor suppressor gene frequently is mutated in human tumors, and this may contribute to chemotherapeutic resistance. We tested the requirement for wild-type p53 in the response of tumor cells to treatment with paclitaxel (trade name Taxol), an antineoplastic agent that...

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PMID: 9275183
DOI: 10.1073/pnas.94.18.9679

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