Article
Cytostatic and cytotoxic effects of recombinant tumor necrosis factor-alpha on sensitive human melanoma cells in vitro may result in selection of cells with enhanced markers of malignancy.
The Journal of investigative dermatology - 1 Dec 1990
Zouboulis C C, Schröder K, Garbe C, Krasagakis K, Krüger S, Orfanos C E
Abstract excerpt
Monolayer cultures of the human melanoma cell lines StML-12, StML-11, StML-14 (third, respectively, twenty-fifth subculture), and SKMel-28 derived from specimens representing different stages of tumor progression were treated with 10-10,000 U/ml rTNF-alpha applied for 72 h. The effects of rTNF-al...
Topics
- Biomarkers, Tumor
- Cell Differentiation
- Cell Division
- Humans
- Melanoma
- Neoplasm Staging
- Phenotype
- Tumor Cells, Cultured
- Tumor Necrosis Factor-alpha