Loss of heterozygosity at the familial RCC t(3;8) locus in most clear cell renal carcinomas.

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Article

Loss of heterozygosity at the familial RCC t(3;8) locus in most clear cell renal carcinomas.

Cancer research - 15 Nov 1995

Druck T, Kastury K, Hadaczek P, Podolski J, Toloczko A, Sikorski A, Ohta M, LaForgia S, Lasota J, McCue P

Abstract excerpt

Previously, we had observed that more than 80% of clear cell renal carcinomas (RCCs) exhibited loss of heterozygosity (LOH) between the microsatellite markers D3S1285 (in 3p14.1) and D3S1295 (in 3p21.1), a region which includes the protein tyrosine phosphatase gamma locus (PTPRG locus, PTP gamma gene) and the 3p14.2 break of the familial RCC-associated translocation, t(3;8)(p14.2;q24), which has been hypothesized...

Topics

Adenocarcinoma, Clear Cell
Aged
Aged, 80 and over
Alleles
Base Sequence
Chromosome Deletion
Chromosome Mapping
Chromosomes, Human, Pair 3
Chromosomes, Human, Pair 8
Female
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Kidney Neoplasms

Male

Middle Aged

Molecular Sequence Data

Protein Tyrosine Phosphatases

Translocation, Genetic

Source

Open in PubMed

Identifiers

PMID: 7585599

Genes

PTPRG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7585599-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Loss of heterozygosity at the familial RCC t(3;8) locus in most clear cell renal carcinomas.PMID 7585599Read ↗

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