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Article

Identification of a 700-kb region of common allelic loss in chromosome bands 3p14.3-p21.1 in human renal cell carcinoma.

Cancer genetics and cytogenetics - 15 Jul 1998

Orikasa K, Orikasa S, Horii A

Abstract excerpt

The short arm of chromosome 3 is considered to harbor one or more of the tumor suppressor genes taking part in the genesis of renal cell carcinoma (RCC). To define the localization of such putative tumor suppressor gene(s), we studied specific allelic loss on chromosome 3p by using 84 samples of RCC with nine microsatellite markers. We defined two commonly deleted regions in 3p14.3-p21.2: (1) region A, a 2-cM...

Topics

Adult
Aged
Aged, 80 and over
Alleles
Carcinoma, Renal Cell
Chromosome Banding
Chromosome Deletion
Chromosomes, Artificial, Yeast
Chromosomes, Human, Pair 3
Female
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

In Situ Hybridization, Fluorescence

Kidney Neoplasms

Loss of Heterozygosity

Male

Middle Aged

Source

Identifiers

PMID: 9666802
DOI: 10.1016/s0165-4608(97)00470-6

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Identification of a 700-kb region of common allelic loss in chromosome bands 3p14.3-p21.1 in human renal cell carcinoma.PMID 9666802Read ↗

Inclusion of new microsatellite repeats in allelic loss analysis excludes retention of heterozygosity in the renal cell carcinoma critical region in 3p21.Semantic proximity Read ↗

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