The rpoS mutant allele of Salmonella typhi Ty2 is identical to that of the live typhoid vaccine Ty21a.

doi:10.1111/j.1574-6968.1999.tb13366.x

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Article

The rpoS mutant allele of Salmonella typhi Ty2 is identical to that of the live typhoid vaccine Ty21a.

FEMS microbiology letters - 1 Jan 1999

Robbe-Saule V, Norel F

Abstract excerpt

Salmonella requires its alternative sigma factor sigma S (RpoS) for virulence in mice. rpoS mutants can be frequently isolated from highly passaged Salmonella laboratory strains. In particular, the live typhoid oral vaccine Salmonella typhi Ty21a and its parental strain Ty2, a 'wild-type' strain...

Topics

Alleles
Amino Acid Sequence
Bacterial Proteins
Bacterial Vaccines
DNA, Bacterial
Molecular Sequence Data
Mutation
Polysaccharides, Bacterial
Salmonella typhi
Sigma Factor
Typhoid-Paratyphoid Vaccines
Vaccines, Attenuated

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