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Article

The rpoS mutant allele of Salmonella typhi Ty2 is identical to that of the live typhoid vaccine Ty21a.

FEMS microbiology letters - 1 Jan 1999

Robbe-Saule V, Norel F

Abstract excerpt

Salmonella requires its alternative sigma factor sigma S (RpoS) for virulence in mice. rpoS mutants can be frequently isolated from highly passaged Salmonella laboratory strains. In particular, the live typhoid oral vaccine Salmonella typhi Ty21a and its parental strain Ty2, a 'wild-type' strain widely used for vaccine development, are rpoS mutants. Here, we show that the nucleotide sequence of the rpoS mutant...

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PMID: 9919662
DOI: 10.1111/j.1574-6968.1999.tb13366.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The rpoS mutant allele of Salmonella typhi Ty2 is identical to that of the live typhoid vaccine Ty21a.PMID 9919662Read ↗

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