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Article

Attenuated typhoid vaccine Salmonella typhi Ty21a: fingerprinting and quality control.

Microbiology (Reading, England) - 1 Aug 1995

McKenna Alison J, Bygraves Jane A, Maiden Martin C J, Feavers Ian M

Abstract excerpt

Live attenuated vaccines, developed with molecular genetical techniques, require new approaches for their quality control. To develop novel quality control tests that enhanced and extended existing procedures, the attenuated vaccine strain Salmonella typhi Ty21a and its parent strain Ty2 were characterized by pulsed-field gel electrophoresis (PFGE) and direct nucleotide sequence analysis. Mutant and parent...

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PMID: 7551062
DOI: 10.1099/13500872-141-8-1993

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