The live oral typhoid vaccine Ty21a is a rpoS mutant and is susceptible to various environmental stresses.

doi:10.1111/j.1574-6968.1995.tb07412.x

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Article

The live oral typhoid vaccine Ty21a is a rpoS mutant and is susceptible to various environmental stresses.

FEMS microbiology letters - 15 Feb 1995

Robbe-Saule V, Coynault C, Norel F

Abstract excerpt

The rpoS (katF) gene, which encodes a RNA polymerase sigma factor (sigma s), regulates the virulence of Salmonella typhimurium in mice. In the present study, we show that rpoS mutants can be frequently found among laboratory strains of Salmonella. In addition, a rpoS mutation was identified in th...

Topics

Bacterial Proteins
Base Sequence
Molecular Sequence Data
Mutation
Plasmids
Polysaccharides, Bacterial
Salmonella typhimurium
Sigma Factor
Typhoid-Paratyphoid Vaccines

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