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Article

Regulation of BMP signaling by the BMP1/TLD-related metalloprotease, SpAN.

Developmental biology - 1 Feb 1999

Wardle F C, Angerer L M, Angerer R C, Dale L

Abstract excerpt

We have used the Xenopus embryo as a test system for analyzing the activity of SpAN, a sea urchin metalloprotease in the astacin family containing BMP1 and tolloid. Embryos expressing SpAN initiated gastrulation on a time scale indistinguishable from controls, but invagination of the vegetal pole...

Topics

Animals
Bone Morphogenetic Protein 1
Bone Morphogenetic Proteins
Carrier Proteins
Embryonic Development
Gastrula
Gene Expression Regulation, Developmental
Glycoproteins
Intercellular Signaling Peptides and Proteins
Metalloendopeptidases
Microinjections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Proteins

RNA, Messenger

Sea Urchins

Xenopus

Source

Identifiers

PMID: 9918695
DOI: 10.1006/dbio.1998.9127

Genes

BMP4
BMP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9918695-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Regulation of BMP signaling by the BMP1/TLD-related metalloprotease, SpAN.PMID 9918695Read ↗

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