Article
XBP1 forms a regulatory loop with BMP-4 and suppresses mesodermal and neural differentiation in Xenopus embryos.
Mechanisms of development - 1 Jan 2006
Cao Ying, Knöchel Sigrun, Oswald Franz, Donow Cornelia, Zhao Hui, Knöchel Walter
Abstract excerpt
The active form of the Xenopus X-box binding protein 1 (xXBP1) partially synergizes and partially antagonizes with BMP-4 signaling. xXBP1 overexpression inhibits mesoderm differentiation and formation of neural tissues. A functional knockdown promotes differentiation of lateral and dorsal mesoderm but not of ventral mesoderm and of neuroectoderm. We show that the active form of xXBP1 in gastrula and early neurula...
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