Article
Sirenomelia in Bmp7 and Tsg compound mutant mice: requirement for Bmp signaling in the development of ventral posterior mesoderm.
Development (Cambridge, England) - 1 May 2005
Zakin Lise, Reversade Bruno, Kuroda Hiroki, Lyons Karen M, De Robertis Eddy M
Abstract excerpt
Sirenomelia or mermaid-like phenotype is one of the principal human congenital malformations that can be traced back to the stage of gastrulation. Sirenomelia is characterized by the fusion of the two hindlimbs into a single one. In the mouse, sirens have been observed in crosses between specific strains and as the consequence of mutations that increase retinoic acid levels. We report that the loss of bone...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.