General numerical treatment of competitive binding kinetics: application to thrombin-dehydrothrombin-hirudin.

doi:10.1006/abio.1998.2670

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Article

General numerical treatment of competitive binding kinetics: application to thrombin-dehydrothrombin-hirudin.

Analytical biochemistry - 1 Feb 1999

KuzmicP

Abstract excerpt

This paper describes a general numerical method for the determination of rate constants that characterize the binding of a ligand L simultaneously and competitively to two different receptor molecules, R1 and R2. The experimental data consist of changes in the concentration of one receptor (e.g.,...

Topics

Animals
Binding, Competitive
Biometry
Confidence Intervals
Hirudins
In Vitro Techniques
Kinetics
Least-Squares Analysis
Mutation
Protein Binding
Software
Thrombin

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