Article
Designing studies to estimate the penetrance of an identified autosomal dominant mutation: cohort, case-control, and genotyped-proband designs.
Genetic epidemiology - 1 Jan 1999
Gail M H, Pee D, Benichou J, Carroll R
Abstract excerpt
One can obtain population-based estimates of the penetrance of a measurable mutation from cohort studies, from population-based case-control studies, and from genotyped-proband designs (GPD). In a GPD, we assume that representative individuals (probands) agree to be genotyped, and one then obtain...
Topics
- Bias
- Breast Neoplasms
- Case-Control Studies
- Cohort Studies
- Female
- Genes, BRCA1
- Genes, Dominant
- Genotype
- Humans
- Likelihood Functions
- Mutation
- Pedigree
- Penetrance
- Regression Analysis
- Research Design
- Risk Factors
- Survival Analysis