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Article

Evaluation of association methods for analysing modifiers of disease risk in carriers of high-risk mutations.

Genetic epidemiology - 1 Apr 2012

Barnes Daniel R, Lee Andrew, Easton Douglas F, Antoniou Antonis C

Abstract excerpt

There is considerable evidence indicating that disease risk in carriers of high-risk mutations (e.g. BRCA1 and BRCA2) varies by other genetic factors. Such mutations tend to be rare in the population and studies of genetic modifiers of risk have focused on sampling mutation carriers through clinical genetics centres. Genetic testing targets affected individuals from high-risk families, making ascertainment of...

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Source

Identifiers

PMID: 22714938
DOI: 10.1002/gepi.21620

Genes

BRCA1
BRCA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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