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Article

Cyclic AMP regulates PDGF-stimulated signal transduction and differentiation of an immortalized optic-nerve-derived cell line.

The Journal of experimental biology - 1 Feb 1999

Cohen R I, Mckay R, Almazan G

Abstract excerpt

To facilitate the study of the molecular events underlying the development of optic-nerve-derived oligodendrocytes and their growth-factor-related signal transduction events, we immortalized perinatal rat optic nerve cells with a temperature-sensitive simian virus 40 large T-antigen, carrying the tsA58 and U19 mutations, via a retrovirus vector. The line, tsU19-9, was selected on the basis of the expression of...

Topics

Animals
Bucladesine
Calcium
Cell Differentiation
Cell Line, Transformed
Colforsin
Inositol Phosphates
Oligodendroglia
Optic Nerve
Phenotype
Platelet-Derived Growth Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein-Tyrosine Kinases

Rats

Signal Transduction

Source

Identifiers

PMID: 9914153
DOI: 10.1242/jeb.202.4.461

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