Article
Neurotransmitter receptor activation triggers p27(Kip1 )and p21(CIP1) accumulation and G1 cell cycle arrest in oligodendrocyte progenitors.
Development (Cambridge, England) - 1 Feb 1999
Ghiani C A, Eisen A M, Yuan X, DePinho R A, McBain C J, Gallo V
Abstract excerpt
We examined the pathways that link neurotransmitter receptor activation and cell cycle arrest in oligodendrocyte progenitors. We had previously demonstrated that glutamate receptor activation inhibits oligodendrocyte progenitor proliferation and lineage progression. Here, using purified oligodend...
Topics
- Animals
- Cell Cycle Proteins
- Cell Differentiation
- Cell Division
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclin-Dependent Kinase Inhibitor p27
- Cyclins
- G1 Phase
- Humans
- Mice
- Microtubule-Associated Proteins
- Oligodendroglia
- Phenotype
- Potassium Channels
- Rats
- Rats, Sprague-Dawley
- Receptors, Adrenergic, beta
- S Phase