Thyroid hormone induces glial lineage of primary neurospheres derived from non‐pathological and pathological rat brain: implications for remyelination‐enhancing therapies

Abstract excerpt

Thyroid hormone exerts a critical role in developmental myelination, acting on the production and maturation of oligodendrocyte, and on the expression of genes encoding for myelin protein. Since remyelination is considered a recapitulation of cellular and molecular events occurring during development, we tested the possibility of stimulating the oligodendroglial lineage and maturation in neurospheres derived from...

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