Article
Inhibition of endogenous phosphodiesterase 7 promotes oligodendrocyte precursor differentiation and survival.
Cellular and molecular life sciences : CMLS - 1 Sept 2013
Medina-Rodríguez E M, Arenzana F J, Pastor J, Redondo M, Palomo V, García de Sola R, Gil C, Martínez A, Bribián A, de Castro F
Abstract excerpt
During the development of the central nervous system (CNS), oligodendrocyte precursors (OPCs) are generated in specific sites within the neural tube and then migrate to colonize the entire CNS, where they differentiate into myelin-forming oligodendrocytes. Demyelinating diseases such as multiple sclerosis (MS) are characterized by the death of these cells. The CNS reacts to demyelination and by promoting...
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