Immature neurons from CNS stem cells proliferate in response to platelet-derived growth factor.

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Article

Immature neurons from CNS stem cells proliferate in response to platelet-derived growth factor.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 May 2001

Erlandsson A, Enarsson M, Forsberg-Nilsson K

Abstract excerpt

Identifying external signals involved in the regulation of neural stem cell proliferation and differentiation is fundamental to the understanding of CNS development. In this study we show that platelet-derived growth factor (PDGF) can act as a mitogen for neural precursor cells. Multipotent stem cells from developing CNS can be maintained in a proliferative state under serum-free conditions in the presence of...

Topics

Animals
Antigens, Differentiation
Bromodeoxyuridine
Cell Count
Cell Differentiation
Cell Division
Cell Survival
Cells, Cultured
Central Nervous System
Immunohistochemistry
Microtubule-Associated Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neurons

Phenotype

Phosphorylation

Platelet-Derived Growth Factor

Protein Serine-Threonine Kinases

Proto-Oncogene Proteins

Proto-Oncogene Proteins c-akt

Source

Open in PubMed Open full text

Identifiers

PMID: 11331377
PMCID: PMC6762483

Genes

FGF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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