Article
kappa-opioid receptor expression defines a phenotypically distinct subpopulation of astroglia: relationship to Ca2+ mobilization, development, and the antiproliferative effect of opioids.
Brain research - 21 Oct 1996
Gurwell J A, Duncan M J, Maderspach K, Stiene-Martin A, Elde R P, Hauser K F
Abstract excerpt
To assess the role of kappa-opioid receptors in astrocyte development, the effect of kappa-agonists on the growth of astroglia derived from 1-2-day-old mouse cerebra was examined in vitro. kappa-Opioid receptor expression was assessed immunocytochemically (using KA8 and KOR1 antibodies), as well as functionally by examining the effect of kappa-receptor activation on intracellular calcium ([Ca2+]i) homeostasis and...
Topics
- 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer
- Analgesics
- Animals
- Astrocytes
- Benzeneacetamides
- Bromodeoxyuridine
- Calcium
- Calcium Channel Blockers
- Cell Count