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Article

MDM2 overexpression is rare in ovarian carcinoma irrespective of TP53 mutation status.

British journal of cancer - 1 Oct 1995

Foulkes W D, Stamp G W, Afzal S, Lalani N, McFarlane C P, Trowsdale J, Campbell I G

Abstract excerpt

Somatic mutations in TP53 are seen in many human cancers. In addition, the protein product of the wild-type TP53 can be sequestered by the protein MDM2 (murine double minute 2). This protein is commonly overexpressed in human sarcomas and gliomas, usually as a result of gene amplification. In thi...

Topics

Chromosome Deletion
Female
Gene Amplification
Gene Expression Regulation, Neoplastic
Humans
Immunohistochemistry
Mutation
Neoplasm Proteins
Nuclear Proteins
Ovarian Neoplasms
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-mdm2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 7547235
DOI: 10.1038/bjc.1995.428
PMCID: PMC2034047

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7547235-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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MDM2 overexpression is rare in ovarian carcinoma irrespective of TP53 mutation status.PMID 7547235Read ↗

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