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Article

MDM2 overexpression is rare in ovarian carcinoma irrespective of TP53 mutation status.

British journal of cancer - 1 Oct 1995

Foulkes W D, Stamp G W, Afzal S, Lalani N, McFarlane C P, Trowsdale J, Campbell I G

Abstract excerpt

Somatic mutations in TP53 are seen in many human cancers. In addition, the protein product of the wild-type TP53 can be sequestered by the protein MDM2 (murine double minute 2). This protein is commonly overexpressed in human sarcomas and gliomas, usually as a result of gene amplification. In this study, 43 ovarian carcinomas (OCs) were analysed for aberrations in the TP53 gene by immunohistochemistry (IHC), loss...

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Share to Chromosome Deletion
Share to Gene Amplification

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Immunohistochemistry

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Share to Nuclear Proteins

Share to Proto-Oncogene Proteins

Share to Tumor Suppressor Protein p53

Source

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Identifiers

PMID: 7547235
DOI: 10.1038/bjc.1995.428
PMCID: PMC2034047

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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